Hydrochloric Acid → HCID 2054580, compound

HRID 654325Notes

Reaction equation

HRID 654325 reaction equation
[C:1]([OH:10])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[SH:4].C([O-])([O-])=O.[K+].[K+].Br[CH2:18][C:19]#[CH:20].Cl>C(C(C)=O)C>[CH2:20]([S:4][C:3]1[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=1[C:1]([OH:10])=[O:9])[C:19]#[CH:18]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 54432-Mercaptobenzoic AcidHCID 7842Propargyl bromideHCID 11430Potassium Carbonate

Product 1

HCID 2054580HCID 2054580, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

To thiosalicylic acid (77 g) slurried in methyl ethyl ketone (500 ml) was added 1 equivalent of K2CO3 followed by 3-bromopropyne (1 equivalent). The reaction mixture was stirred for 3 hours and then poured into 1N HCl and the solids filtered and then vacuum dried to afford the subtitle compound.

Workup

  1. filtrationthe solids filtered
  2. customvacuum dried

Sources & evidence

ORD record
ord-d40b49e8a13b43429115b31ce5cdeb2a
Source dataset
uspto-grants-1992_07
Patent number
US05130485

Reaction notes

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