反应详情

N-(2-Butenyl)-N-(3-trifluoromethylphenyl)-2-bromo-2-(4-fluorophenyl)acetamide (1.9 g) was added to 20 ml of toluene, followed by the addition of 1.2 ml of tributyltin hydride and an extremely small amount of α,α-azobisisobutyronitrile (AIBN) under stirring at 70° C. After the reaction mixture was continuously stirred for 1 hour, 60 ml of 20% hydrochloric acid were added, followed by extraction with toluene. After the extract was dried over anhydrous sodium sulfate, the extract was concentrated in an evaporator and then subjected to chromatography on a silica gel column. The 3,4-trans isomer (0.9 g) and the 3,4-cis isomer (0.27 g) were obtained.

1. extractionfollowed by extraction with toluene
2. dry with materialAfter the extract was dried over anhydrous sodium sulfate
3. concentrationthe extract was concentrated in an evaporator
4. customThe 3,4-trans isomer (0.9 g) and the 3,4-cis isomer (0.27 g) were obtained