Hydrochloric Acid → HCID 86638830, compound

HRID 655109Notes

Reaction equation

HRID 655109 reaction equation
[C:1]([O:7][CH2:8][C@@H:9]([NH:11]C(OC(C)(C)C)=O)[CH3:10])(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3].[ClH:19].O1CCOCC1>CCOC(C)=O>[ClH:19].[NH2:11][C@@H:9]([CH3:10])[CH2:8][O:7][C:1](=[O:6])[C:2]([CH3:4])([CH3:3])[CH3:5]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 59185401HCID 59185401, compound

Product 1

HCID 86638830HCID 86638830, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of (2S)-2-[(tert-butoxycarbonyl)-amino]-propyl pivaloate (1.0 eq.) in EtOAc (0.6 M) was added 4N HCl in dioxane (10 eq.). The reaction mixture was stirred for 2.5 h and then the solvent was evaporated in vacuo to give a solid that was washed with Et2O and dried.

Workup

  1. customthe solvent was evaporated in vacuo
  2. customto give a solid
  3. washthat was washed with Et2O
  4. customdried

Sources & evidence

ORD record
ord-16a40a4ffab941b18951a14abaa35f13
Source dataset
uspto-grants-2011_12
Patent number
US08071568B2

Reaction notes

Loading…