3-Pyridinemethanol → Phthalimide

HRID 656566Notes

Reaction equation

HRID 656566 reaction equation
N1C=CC=C(CO)C=1.O[N:10]1[C:14](=[O:15])[C:13]2=[CH:16][CH:17]=[CH:18][CH:19]=[C:12]2[C:11]1=[O:20]>>[C:14]1(=[O:15])[NH:10][C:11](=[O:20])[C:12]2=[CH:19][CH:18]=[CH:17][CH:16]=[C:13]12

Participants

3

Reactant 2

HCID 75103-PyridinemethanolHCID 10665N-Hydroxyphthalimide

Product 1

HCID 6809PhthalimideYield 81.3%

Procedure

Phthalimide-protected intermediate 2G was prepared from pyridin-3-ylmethanol and N-hydroxyphthalimide by a procedure analogous to Example 2A, Step 1 (3.22 g, 81.3% yield). ESI-MS: m/z 255.2 (M+H)+.

Sources & evidence

ORD record
ord-6345d91ae214497ca79c72e1d29ff0f8
Source dataset
uspto-grants-2011_12
Patent number
US08071766B2

Reaction notes

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