反应详情

7-Fluoropyrido[2,3-b]pyrazin-2(1H)-one (306 mg, 1.855 mmol) was suspended in dry DMF (10 mL) under argon at rt, and the stirred suspension was treated with K2CO3 (845 mg, 6.12 mmol) and allyl iodide (223 μl, 2.41 mmol). It was then stirred for 1 h before addition of water (100 ml). The mixture was then extracted with DCM (2×200 ml) and 5% MeOH/DCM (100 ml). The combined organic extracts were dried over anhydrous magnesium sulphate, filtered and evaporated and purified by column chromatography on silica with a 0-10% MeOH in DCM gradient to give the desired product as a yellow solid (177 mg, 47%).

1. extractionThe mixture was then extracted with DCM (2×200 ml) and 5% MeOH/DCM (100 ml)
2. dry with materialThe combined organic extracts were dried over anhydrous magnesium sulphate
3. filtrationfiltered
4. customevaporated
5. custompurified by column chromatography on silica with a 0-10% MeOH in DCM gradient