反应详情

A solution of 6,7-difluoro-2(1H)-quinoxalinone (0.57 g; 3.13 mmol) in dry DMF (10 ml) containing anhydrous potassium carbonate (1.3 g; 9.4 mmol) was treated with allyl iodide (0.31 ml; 3.45 mmol) and the mixture was stirred at rt for 2 h. The solvents were evaporated, water was added and the mixture was extracted (3×) with DCM. The extracts were dried and evaporated, and the residue was chromatographed on silica gel, eluting with 0-50% ethyl acetate/hexane to give the product (0.44 g, 63%).

1. customThe solvents were evaporated
2. additionwater was added
3. extractionthe mixture was extracted (3×) with DCM
4. customThe extracts were dried
5. customevaporated
6. customthe residue was chromatographed on silica gel
7. washeluting with 0-50% ethyl acetate/hexane