反应详情

温度

40 °C

A mixture of 2-chloro-6-(methyloxy)-3-nitropyridine (10 g, 53 mmol), aminoacetaldehyde dimethylacetal (5.6 g, 6.2 ml, 53 mmol) and potassium carbonate (7.4 g, 53 mmol) in acetonitrile (100 mL) and DMF (10 mL) was heated at 40° C. for 30 minutes. The mixture was filtered and extracted with DCM and brine. The organic extract was added to a silica column which was then eluted with 0-100% ethyl acetate in hexane affording a yellow solid (12.4 g, 90%).

1. filtrationThe mixture was filtered
2. extractionextracted with DCM and brine
3. extractionThe organic extract
4. additionwas added to a silica column which
5. washwas then eluted with 0-100% ethyl acetate in hexane affording a yellow solid (12.4 g, 90%)