Methylamine → HCID 68975097, compound

HRID 657563Notes

Reaction equation

HRID 657563 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[CH:8]([CH2:14][N:15](C)[CH2:16][CH2:17][C:18]([N:20]1[CH2:26][CH2:25][C:24]3[CH:27]=[C:28](OC)[C:29]([O:31][CH3:32])=[CH:30][C:23]=3[CH2:22][CH2:21]1)=[O:19])[CH2:7]2.COC1C(OC)=CC2CC(=O)NC=CC=2C=1.COC1C=CC2C=CNC(=O)CC=2C=1.CN.COC1C=C2C(=CC=1OC)[C@@H](CN)C2>O1CCOCC1.C1COCC1>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[C@@H:8]([CH2:14][NH:15][CH2:16][CH2:17][C:18]([N:20]1[CH2:26][CH2:25][C:24]3[CH:27]=[CH:28][C:29]([O:31][CH3:32])=[CH:30][C:23]=3[CH2:22][CH2:21]1)=[O:19])[CH2:7]2

Participants

8

Reactant 5

HCID 6329MethylamineHCID 14823731,3-Dihydro-7,8-dimethoxy-2H-3-benzazepin-2-oneHCID 42200938-methoxy-2,3-dihydro-1H-3-benzazepin-2-oneHCID 115066164,5-Dimethoxy-1-(aminomethyl)benzocyclobutane, (S)-HCID 68972400N-[(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl]-3-(7,8-dimethoxy-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-N-methyl-3-oxopropan-1amine hydrochloride

Product 1

HCID 68975097HCID 68975097, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 312751,4-DioxaneSolvent

Procedure

Obtained in the same manner as the product of Example 1, but with replacement, in Step 1, of the 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one by 8-methoxy-1,3-dihydro-2H-3-benzazepin-2-one and, in Step 4, of the racemic (3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl]methylamine by {[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}amine and of the THF by dioxane.

Sources & evidence

ORD record
ord-1cd759714e554dd2b99c3db9c72976b2
Source dataset
uspto-grants-2011_12
Patent number
US08076325B2

Reaction notes

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