Hydrochloric Acid → HCID 66764225, compound

HRID 657600Notes

Reaction equation

HRID 657600 reaction equation
[Cl:1][C:2]1[N:7]=[N:6][C:5]([C:8]23[CH2:15][N:12]([CH2:13][CH2:14]2)[CH2:11][CH2:10][CH2:9]3)=[CH:4][CH:3]=1.CS[C:18]1[S:22][C:21](B(O)O)=[CH:20][CH:19]=1.Cl.[CH3:27]C(O)C>>[ClH:1].[CH3:27][C:18]1[S:22][C:21]([C:2]2[N:7]=[N:6][C:5]([C:8]34[CH2:15][N:12]([CH2:13][CH2:14]3)[CH2:11][CH2:10][CH2:9]4)=[CH:4][CH:3]=2)=[CH:20][CH:19]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 2794627[5-(Methylsulfanyl)thiophen-2-yl]boronic acidHCID 57528563HCID 57528563, compound

Product 1

HCID 66764225HCID 66764225, compound

Procedure

This compound is obtained according to the method described in stage 1.6 of Example 1, using 5-(6-chloropyridazin-3-yl)-1-azabicyclo[3.2.1]octane, prepared according to stage 1.5 of Example 1, and 5-methylsulfanyl-2-thienylboronic acid. The hydrochloride thereof is prepared by treatment of the base with a solution of hydrochloric acid in propan-2-ol, and the crystals obtained are collected by filtration and dried under vacuum.

Workup

  1. customThis compound is obtained
  2. customprepared
  3. customthe crystals obtained
  4. filtrationare collected by filtration
  5. customdried under vacuum

Sources & evidence

ORD record
ord-f8cd46309ec0442f95f5ea7d5fe1068b
Source dataset
uspto-grants-2011_12
Patent number
US08076340B2

Reaction notes

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