1-Bromo-3-chloropropane → HCID 16781905, compound

HRID 657610Notes

Reaction equation

HRID 657610 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]#[N:10])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:18][CH2:19][CH2:20][Cl:21]>CN(C)C=O>[Cl:21][CH2:20][CH2:19][CH2:18][O:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]#[N:10])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 80061-Bromo-3-chloropropaneHCID 11430Potassium CarbonateHCID 265484-Hydroxybenzyl cyanide

Product 1

HCID 16781905HCID 16781905, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Following the procedure described in example 1§E, but starting from 4-hydroxyphenylacetonitrile (4.65 g), potassium carbonate (24 g) and 1-bromo-3-chloropropane (17.3 mL) in N,N-dimethylformamide (23 mL) affords 6.86 g of 4-(3-chloropropoxy)phenylacetonitrile as a yellow solid.

Sources & evidence

ORD record
ord-4cdd8f7cfa3c4a71a921a6c1436c87d0
Source dataset
uspto-grants-2011_12
Patent number
US08076329B2

Reaction notes

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