1-Bromo-3-chloropropane → HCID 23150311, compound

HRID 657633Notes

Reaction equation

HRID 657633 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[CH3:14])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:22][CH2:23][CH2:24][Cl:25]>CN(C)C=O>[Cl:25][CH2:24][CH2:23][CH2:22][O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[CH3:14])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 80061-Bromo-3-chloropropaneHCID 11430Potassium CarbonateHCID 11629708HCID 11629708, compound

Product 1

HCID 23150311HCID 23150311, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Following the procedure described in example 1§E, but starting from 4-hydroxy-2′-methylbiphenyl (0.55 g), potassium carbonate (2.07 g) and 1-bromo-3-chloropropane (1.48 mL) in N,N-dimethylformamide (20 mL) affords 913 mg of 4-(3-chloropropoxy)-2′-methylbiphenyl used without further purification.

Sources & evidence

ORD record
ord-c211e2e3b558498b99491a1bfaea36dc
Source dataset
uspto-grants-2011_12
Patent number
US08076329B2

Reaction notes

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