1-Bromo-3-chloropropane → HCID 23150295, compound

HRID 657634Notes

Reaction equation

HRID 657634 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[CH:11][CH:10]=[CH:9]2)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:20][CH2:21][CH2:22][Cl:23]>CN(C)C=O>[Cl:23][CH2:22][CH2:21][CH2:20][O:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[CH:11][CH:10]=[CH:9]2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 80061-Bromo-3-chloropropaneHCID 11430Potassium CarbonateHCID 90072p-(1H-Pyrrol-1-yl)phenol

Product 1

HCID 23150295HCID 23150295, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Following the procedure described in example 1§E, but starting from 1-(4-hydroxyphenyl)pyrrole (0.8 g), potassium carbonate (3.2 g) and 1-bromo-3-chloropropane (2.5 mL) in N,N-dimethylformamide (10 mL) affords 1.37 g of 1-[4-(3-chloropropoxy)phenyl]pyrrole as a brown solid used without further purification.

Sources & evidence

ORD record
ord-cf7a1cf42d9648de9993ed1435fc7adb
Source dataset
uspto-grants-2011_12
Patent number
US08076329B2

Reaction notes

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