反应详情

温度

50 °C

1-(3-Hydroxy-5-methoxyphenyl)ethanone (O3.033; 1.5 g) and bromomethylcyclohexane (1.76 g) were dissolved in DMF (20 ml), and sodium hydride (260 mg) was added. After stirring at 50° C. for 24 h, the DMF was drawn off. The residue was taken up in EA, washed with water, dried, filtered and concentrated. The residue was purified using silica gel (40 g cartridge, n-heptane/EA 0-50% within 30 min). 1.33 g of the title compound were obtained. LC-MS rt: 1.93 min [M+H]+: 263.2 (met. a)

1. washwashed with water
2. customdried
3. filtrationfiltered
4. concentrationconcentrated
5. customThe residue was purified
6. customsilica gel (40 g cartridge, n-heptane/EA 0-50% within 30 min)