Potassium Carbonate → HCID 59549299, compound

HRID 658903Notes

Reaction equation

HRID 658903 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:10])=[C:6]([CH:9]=1)[CH:7]=[O:8].[CH2:11]([O:13][C:14](=[O:19])[C:15](Br)([CH3:17])[CH3:16])C.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[CH3:11][O:13][C:14](=[O:19])[C:15]([O:10][C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:9][C:6]=1[CH:7]=[O:8])([CH3:17])[CH3:16]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 124815-Chloro-salicylaldehyde

Product 1

HCID 59549299HCID 59549299, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
110 °C

Procedure

A mixture of 5-chloro-2-hydroxy-benzaldehyde (7 g, 45 mmol), 2-bromo-2-methyl-propionic acid ethyl ester (10.4 g, 58 mmol), K2CO3 (18.6 g, 135 mmol) and KI (0.97 g, 5.8 mmol) in DMF (20 mL) was heated at 110° C. for 3 h. Then the mixture was filtered and the filtrate was concentrated. The residue was used into next step reaction without further purification (7 g).

Workup

  1. filtrationThen the mixture was filtered
  2. concentrationthe filtrate was concentrated
  3. customThe residue was used into next step reaction without further purification (7 g)

Sources & evidence

ORD record
ord-985fe21956bd4ae7adb2e60bb36032f6
Source dataset
uspto-grants-2011_12
Patent number
US08076482B2

Reaction notes

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