Dimethylformamide → HCID 178464568, compound

HRID 659049Notes

Reaction equation

[F:1][C:2]([F:6])([F:5])[CH2:3][NH2:4].[C:7]([N:14]1[CH:18]=[CH:17]N=[CH:15]1)([N:9]1C=CN=[CH:10]1)=O.CN(C=[O:23])C>>[CH3:10]/[N:9]=[CH:7]\[N:14]([CH:18]=[CH2:17])[C:15]([NH:4][CH2:3][C:2]([F:6])([F:5])[F:1])=[O:23]

Participants

Reactant 3

HCID 6228Dimethylformamide

HCID 9773Ethanamine, 2,2,2-trifluoro-

HCID 682631,1'-Carbonyldiimidazole

Product 1

HCID 178464568HCID 178464568, compound

Procedure

TEA (1.3 mL, 0.8 mmol) was added to a solution of 2,2,2-trifluoroethylamine (72 mg, 1 mmol) and 1,1′-carbonyldiimidazole (135 mg, 0.8 mmol) in DMF (4 mL) (clear colorless solution). The solution was used for the synthesis of compound 5 without further isolation of compound 5a.

Sources & evidence

ORD record: ord-9b0ba0269e4b461aa12d78ae8c95a475
Source dataset: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08080556B2

Reaction notes

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