反应详情

温度

50 °C

A mixture of methyl 2-(bromoethyl)-5-chlorobenzoate (100 mg, 0.38 mmol), 2-chlorophenol (43 μL, 0.42 mmol) and potassium carbonate (105 mg, 0.76 mmol) in N,N-dimethylforamide (2 mL) was stirred at room temperature for 3 h and at 50° C. for 4 hours. Water (5 mL) was added and the mixture was extracted with diethyl ether (15 mL×2). The combined organic extracts were washed with brine (15 mL) and dried (sodium sulfate). After removal of solvent, the residue was purified by pTLC eluting with hexane/ethyl acetate (9/1) to afford 103 mg (87%) of the title compound:

1. extractionthe mixture was extracted with diethyl ether (15 mL×2)
2. washThe combined organic extracts were washed with brine (15 mL)
3. dry with materialdried (sodium sulfate)
4. customAfter removal of solvent
5. customthe residue was purified by pTLC
6. washeluting with hexane/ethyl acetate (9/1)