Dimethylformamide → HCID 57811338, compound

HRID 660431Notes

Reaction equation

HRID 660431 reaction equation
Br[CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].C(=O)([O-])[O-].[K+].[K+].[CH3:14][C:15]1[C:24]2[C:19](=[CH:20][C:21]([CH3:25])=[CH:22][CH:23]=2)[C:18]([N:26]2[CH:30]=[N:29][N:28]=[C:27]2[SH:31])=[CH:17][CH:16]=1.CN(C=O)C>C1COCC1.O>[CH3:14][C:15]1[C:24]2[C:19](=[CH:20][C:21]([CH3:25])=[CH:22][CH:23]=2)[C:18]([N:26]2[CH:30]=[N:29][N:28]=[C:27]2[S:31][CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4])=[CH:17][CH:16]=1

Participants

7

Reactant 4

HCID 6228DimethylformamideHCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 178422678HCID 178422678, compound

Product 1

HCID 57811338HCID 57811338, compoundYield 86.4%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

Ethyl 2-bromoacetate (87 μL, 0.783 mmol) and Potassium carbonate (0.216 g, 1.57 mmol) were added to a solution of 4-(4,7-Dimethylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiol (0.2 g, 0.783 mmol) in THF (3.1 mL). The resulting mixture was then heated to 60° C. for 1 hour. Additional DMF (1 mL) was added and the mixture heated at 60° C. for 18 hours. Water (3 mL) was added and the mixture extracted with ethyl acetate (3×3 mL). The combined organic extracts were dried over sodium sulfate, filtered, concentrated and Purified by SGC (0-100% EtOAc/Hexanes) to afford ethyl 2-(4-(4,7-dimethylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetate as a clear oil (0.231 g, 86%).

Workup

  1. temperaturethe mixture heated at 60° C. for 18 hours
  2. extractionthe mixture extracted with ethyl acetate (3×3 mL)
  3. dry with materialThe combined organic extracts were dried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customPurified by SGC (0-100% EtOAc/Hexanes)

Sources & evidence

ORD record
ord-d8a77cacef66478d8a649a596dfc6ef1
Source dataset
uspto-grants-2011_12
Patent number
US08084483B2

Reaction notes

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