反应详情

To a solution of pyrazole (2.0 g, 29 mmol) in DMF (20 mL) is added potassium carbonate (12.4 g, 90 mmol) and benzyloxymethylchloride (4 mL, 32.3 mmol). The reaction is stirred for four days, then poured into water and extracted with EtOAc . The organic layer is washed with 1 N NaOH, dried over MgSO4 and concentrated. The residue is purified by column chromatography using EtOAc as eluent to afford the title compound as a light yellow oil: (M+1)+=189.

1. extractionextracted with EtOAc
2. washThe organic layer is washed with 1 N NaOH
3. dry with materialdried over MgSO4
4. concentrationconcentrated
5. customThe residue is purified by column chromatography