反应详情

温度

60 °C

To a mixture of 2-trimethylsilanylethyl (4-amino-3-benzyloxyphenoxy)acetate (4.56 g, 12.2 mmol) and potassium carbonate (3.37 g, 24.4 mmol) in DMF (25 mL) is added methyl bromoacetate (1.87 g, 12.2 mmol). The mixture is stirred at 60° C. for 1 h then is allowed to cool to RT. It is poured into water and extracted with EtOAc and the organic phase is washed with water (1×), brine (5×), and dried over Na2SO4. The solvent is removed under reduced pressure to afford the title compound which is used directly in the next step.

1. temperatureto cool to RT
2. extractionextracted with EtOAc
3. washthe organic phase is washed with water (1×), brine (5×)
4. dry with materialdried over Na2SO4
5. customThe solvent is removed under reduced pressure