反应详情

温度

65 °C

A mixture of 2-hydroxy-4-methoxy-1-nitrobenzene (520 mg, 3.08 mmol), benzyl bromide (522 mg, 3.08 mmol) and potassium carbonate (637 mg, 4.61 mmol) in DMF (3 mL) is stirred at 65° C. for 18 h. The mixture is poured into water and the mixture extracted with EtOAc. The organic phase is washed with water (3×) and brine (1×) and is dried over sodium sulfate. The solvent is removed under reduced pressure to give the title compound as an oil.

1. extractionthe mixture extracted with EtOAc
2. washThe organic phase is washed with water (3×) and brine (1×)
3. dry with materialis dried over sodium sulfate
4. customThe solvent is removed under reduced pressure