反应详情

温度

85 °C

To a suspension of 4-chloro-2-hydroxybenzoic acid (10.0 g, 57.9 mmol) and K2CO3 (20.8 g, 151 mmol) in DMF (115 mL) is added benzyl bromide (14.5 mL, 122 mmol) and the mixture is stirred at 85° C. for 7 h. The mixture is allowed to cool to RT and is partitioned between EtOAc and 1N HCl. The organic phase is washed with 1N HCl and brine then is dried over sodium sulfate. The solvent is removed under reduced pressure to give the title compound which is used directly in the next step.

1. temperatureto cool to RT
2. customis partitioned between EtOAc and 1N HCl
3. washThe organic phase is washed with 1N HCl and brine
4. dry with materialthen is dried over sodium sulfate
5. customThe solvent is removed under reduced pressure