反应详情

(3H-Imidazol-4-yl)-methanol (90 mg, 0.92 mmol) obtained by reducing 3H-imidazole-4-carboaldehyde (commercial product) with lithium aluminum hydride in THF was mixed with PPh3 (245 mg, 0.94 mmol), N-hydroxy-phthalimide (153 mg, 0.94 mmol), and diisopropyl azodicarboxylate (189 mg, 0.94 mmol) in anhydrous THF at 0° C. under a nitrogen atmosphere, and the mixture was stirred. After 4 hours, the reaction mixture was purified by silica gel chromatography to give 2-(3H-imidazol-4-ylmethoxy)-isoindol-1,3-dione (30 mg).

1. customthe reaction mixture was purified by silica gel chromatography