Hydrochloric Acid → 7-Chloro-2-(2-hydroxymethylbenzofuran-5-yl)quinoline

HRID 663084Notes

Reaction equation

HRID 663084 reaction equation
[Al+3:26].[Cl:1][c:2]1[cH:3][cH:4][c:5]2[cH:6][cH:7][c:8](-[c:12]3[cH:13][cH:14][c:15]4[c:16]([cH:17][c:18]([C:20](=[O:21])[O:22][CH3:23])[o:19]4)[cH:24]3)[n:9][c:10]2[cH:11]1.[ClH:31].[H-:25].[H-:28].[H-:29].[H-:30].[Li+:27].[O:32]1[CH2:33][CH2:34][CH2:35][CH2:36]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[cH:6][cH:7][c:8](-[c:12]3[cH:13][cH:14][c:15]4[c:16]([cH:17][c:18]([CH2:20][OH:21])[o:19]4)[cH:24]3)[n:9][c:10]2[cH:11]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 229221827-Chloro-2-(2-methoxycarbonylbenzofuran-5-yl)quinoline

Product 1

HCID 229222147-Chloro-2-(2-hydroxymethylbenzofuran-5-yl)quinoline

Sources & evidence

ORD record
ord-a8926980ab384327a8c93e394c543a93
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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