Hydrochloric Acid → N-{1-[6-Amino-2-(methylsulfanyl)-4-pyrimidinyl]-4-piperidinyl}-3,4-dichloro-5-methyl-1H-pyrrole-2-carboxamide

HRID 665122Notes

Reaction equation

HRID 665122 reaction equation
[CH:1]([N:2]([CH:3]([CH3:4])[CH3:5])[CH2:6][CH3:7])([CH3:8])[CH3:9].[Cl:34][c:35]1[c:36]([C:42](=[O:43])[NH:44][CH:45]2[CH2:46][CH2:47][N:48]([c:49]3[cH:50][c:51](-[c:52]4[n:53][cH:54][o:55][n:56]4)[cH:57][c:58]([Cl:59])[n:60]3)[CH2:61][CH2:62]2)[nH:37][c:38]([CH3:41])[c:39]1[Cl:40].[ClH:63].[NH2:64][CH:65]1[CH2:66][CH2:67][N:68]([c:71]2[cH:72][c:73]([NH2:79])[n:74][c:75]([S:77][CH3:78])[n:76]2)[CH2:69][CH2:70]1.[O:80]=[CH:81][N:82]([CH3:83])[CH3:84].[P-:10]([F:11])([F:12])([F:13])([F:14])([F:15])[F:16].[n:17]1([O:18][C:19]([N:20]([CH3:21])[CH3:22])=[N+:23]([CH3:24])[CH3:25])[c:26]2[n:27][cH:28][cH:29][cH:30][c:31]2[n:32][n:33]1>>[Cl:34][c:35]1[c:36]([C:42](=[O:43])[NH:64][CH:65]2[CH2:66][CH2:67][N:68]([c:71]3[cH:72][c:73]([NH2:79])[n:74][c:75]([S:77][CH3:78])[n:76]3)[CH2:69][CH2:70]2)[nH:37][c:38]([CH3:41])[c:39]1[Cl:40]

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 685798446-(4-Aminopiperidin-1-yl)-2-methylsulfanylpyrimidin-4-amineHCID 866083163,4-Dichloro-N-{1-[6-chloro-4-(1,2,4-oxadiazol-3-yl)-2-pyridinyl]-4-piperidinyl}-5-methyl-1H-pyrrole-2-carboxamide

Product 1

HCID 68579878N-{1-[6-Amino-2-(methylsulfanyl)-4-pyrimidinyl]-4-piperidinyl}-3,4-dichloro-5-methyl-1H-pyrrole-2-carboxamide

Sources & evidence

ORD record
ord-225940ac9230498782aaef9d28703e0b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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