Ammonium → 1-(Tert-butyl) 3-methyl 4-(4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)phenyl)-5,6-dihydropyridine-1,3(2h)-dicarboxylate
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[Si:5]([O:6][CH2:7][CH2:8][O:9][c:10]1[cH:11][cH:12][c:13]([Br:16])[cH:14][cH:15]1)([CH3:17])[CH3:18].[CH2:51]1[O:52][CH2:53][CH2:54][CH2:55]1.[CH3:133][CH2:134][O:135][C:136]([CH3:137])=[O:138].[CH3:19][CH2:20][CH2:21][CH2:22][Li:23].[CH3:24][O:25][C:26](=[O:27])[C:28]1=[C:33]([O:34][S:35]([C:36]([F:37])([F:38])[F:39])(=[O:40])=[O:41])[CH2:32][CH2:31][N:30]([C:42](=[O:43])[O:44][C:45]([CH3:46])([CH3:47])[CH3:48])[CH2:29]1.[Cl-:49].[NH4+:50].[cH:56]1[cH:57][cH:58][c:59]([P:60]([Pd:61]([P:62]([c:63]2[cH:64][cH:65][cH:66][cH:67][cH:68]2)([c:69]2[cH:70][cH:71][cH:72][cH:73][cH:74]2)[c:75]2[cH:76][cH:77][cH:78][cH:79][cH:80]2)([P:81]([c:82]2[cH:83][cH:84][cH:85][cH:86][cH:87]2)([c:88]2[cH:89][cH:90][cH:91][cH:92][cH:93]2)[c:94]2[cH:95][cH:96][cH:97][cH:98][cH:99]2)[P:100]([c:101]2[cH:102][cH:103][cH:104][cH:105][cH:106]2)([c:107]2[cH:108][cH:109][cH:110][cH:111][cH:112]2)[c:113]2[cH:114][cH:115][cH:116][cH:117][cH:118]2)([c:119]2[cH:120][cH:121][cH:122][cH:123][cH:124]2)[c:125]2[cH:126][cH:127][cH:128][cH:129][cH:130]2)[cH:131][cH:132]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[Si:5]([O:6][CH2:7][CH2:8][O:9][c:10]1[cH:11][cH:12][c:13]([C:33]2=[C:28]([C:26]([O:25][CH3:24])=[O:27])[CH2:29][N:30]([C:42](=[O:43])[O:44][C:45]([CH3:46])([CH3:47])[CH3:48])[CH2:31][CH2:32]2)[cH:14][cH:15]1)([CH3:17])[CH3:18]Participants
9
Reactant 8
HCID 223Ammonium
HCID 312Chloride
HCID 8028Tetrahydrofuran
HCID 8857Ethyl Acetate
HCID 150978074-[2-(Tert-butyldimethylsilanyloxy)ethoxy]bromobenzene
HCID 152219361-Tert-butyl 3-methyl 4-(trifluoromethanesulfonyloxy)-1,2,5,6-tetrahydropyridine-1,3-dicarboxylate
HCID 178418339Butyllithium
HCID 178420554HCID 178420554, compoundProduct 1
Sources & evidence
- ORD record
- ord-c44cd3b37aa745f4a2e37a0d731d423e
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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