Dimethylformamide → HCID 59447598, compound

HRID 666149Notes

Reaction equation

HRID 666149 reaction equation
[C:41](#[CH:42])[c:43]1[cH:44][c:45]2[cH:46][cH:47][c:48]([O:53][CH2:54][CH2:55][CH2:56][N:57]3[CH2:58][CH2:59][O:60][CH2:61][CH2:62]3)[cH:49][c:50]2[cH:51][cH:52]1.[Cu:109][I:110].[O:63]=[CH:64][N:65]([CH3:66])[CH3:67].[Pd:68]([Cl:69])[Cl:70].[c:71]1([P:72]([c:73]2[cH:74][cH:75][cH:76][cH:77][cH:78]2)[c:79]2[cH:80][cH:81][cH:82][cH:83][cH:84]2)[cH:85][cH:86][cH:87][cH:88][cH:89]1.[c:90]1([P:91]([c:92]2[cH:93][cH:94][cH:95][cH:96][cH:97]2)[c:98]2[cH:99][cH:100][cH:101][cH:102][cH:103]2)[cH:104][cH:105][cH:106][cH:107][cH:108]1.[s:1]1[c:2]([N:10]([C:11](=[O:12])[c:13]2[cH:14][cH:15][cH:16][c:17]3[c:22]2[CH2:21][N:20]([c:23]2[s:24][c:25]([I:32])[c:26]([C:28](=[O:29])[O:30][CH3:31])[n:27]2)[CH2:19][CH2:18]3)[CH2:33][O:34][CH2:35][CH2:36][Si:37]([CH3:38])([CH3:39])[CH3:40])[n:3][c:4]2[c:5]1[cH:6][cH:7][cH:8][cH:9]2>>[s:1]1[c:2]([N:10]([C:11](=[O:12])[c:13]2[cH:14][cH:15][cH:16][c:17]3[c:22]2[CH2:21][N:20]([c:23]2[s:24][c:25]([C:42]#[C:41][c:43]4[cH:44][c:45]5[cH:46][cH:47][c:48]([O:53][CH2:54][CH2:55][CH2:56][N:57]6[CH2:58][CH2:59][O:60][CH2:61][CH2:62]6)[cH:49][c:50]5[cH:51][cH:52]4)[c:26]([C:28](=[O:29])[O:30][CH3:31])[n:27]2)[CH2:19][CH2:18]3)[CH2:33][O:34][CH2:35][CH2:36][Si:37]([CH3:38])([CH3:39])[CH3:40])[n:3][c:4]2[c:5]1[cH:6][cH:7][cH:8][cH:9]2

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 594476024-(3-(6-Ethynylnaphthalen-2-yloxy)propyl)morpholineHCID 59447651methyl 2-(8-(benzo[d]thiazol-2-yl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-iodothiazole-4-carboxylate

Product 1

HCID 59447598HCID 59447598, compound

Sources & evidence

ORD record
ord-5513a909b2434236a9715428759e613f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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