Propargyl alcohol → 3-(3-thienyl)-2-propyn-1-ol

HRID 667354Notes

Reaction equation

HRID 667354 reaction equation
[Br:1][c:2]1[cH:3][s:4][cH:5][cH:6]1.[CH2:7]([C:8]#[CH:9])[OH:10].[CH:11]([NH:12][CH:13]([CH3:14])[CH3:15])([CH3:16])[CH3:17].[Cu:59][I:60].[Pd:18]([Cl:19])[Cl:20].[c:21]1([P:22]([c:23]2[cH:24][cH:25][cH:26][cH:27][cH:28]2)[c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)[cH:35][cH:36][cH:37][cH:38][cH:39]1.[c:40]1([P:41]([c:42]2[cH:43][cH:44][cH:45][cH:46][cH:47]2)[c:48]2[cH:49][cH:50][cH:51][cH:52][cH:53]2)[cH:54][cH:55][cH:56][cH:57][cH:58]1>>[c:2]1([C:9]#[C:8][CH2:7][OH:10])[cH:3][s:4][cH:5][cH:6]1

Participants

7

Reactant 6

HCID 7859Propargyl alcoholHCID 7912DiisopropylamineHCID 11776Triphenylphosphine2×HCID 133833-BromothiopheneHCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

Product 1

HCID 121814443-(3-thienyl)-2-propyn-1-ol

Sources & evidence

ORD record
ord-c9800861823a4bad8fe32833494a89e0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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