Dimethylformamide → 2-(6-Amino-8-(2-pyridin-3-yl-ethynyl)-purin-9-yl)ethanol

HRID 667824Notes

Reaction equation

HRID 667824 reaction equation
[C:15](#[CH:16])[c:17]1[cH:18][n:19][cH:20][cH:21][cH:22]1.[CH3:23][CH2:24][N:25]([CH2:26][CH3:27])[CH2:28][CH3:29].[Cu:35][I:36].[NH2:1][c:2]1[c:3]2[n:4][c:5]([Br:14])[n:6]([CH2:11][CH2:12][OH:13])[c:7]2[n:8][cH:9][n:10]1.[O:30]=[CH:31][N:32]([CH3:33])[CH3:34]>>[NH2:1][c:2]1[c:3]2[n:4][c:5]([C:16]#[C:15][c:17]3[cH:18][n:19][cH:20][cH:21][cH:22]3)[n:6]([CH2:11][CH2:12][OH:13])[c:7]2[n:8][cH:9][n:10]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 1860033-EthynylpyridineHCID 445724692-(6-amino-8-bromo-9H-purin-9-yl)ethanol

Product 1

HCID 668679042-(6-Amino-8-(2-pyridin-3-yl-ethynyl)-purin-9-yl)ethanol

Sources & evidence

ORD record
ord-4f450fa66e5b4089957ea368d13bd68d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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