Methanol → 2,6-Dichloro-N-(4-chloro-3-(2-(2-(dimethylamino)ethylamino)-8-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-isonicotinamide

HRID 673724Notes

Reaction equation

HRID 673724 reaction equation
[CH2:72]1[O:73][CH2:74][CH2:75][CH2:76]1.[CH3:80][OH:81].[CH:12]([N:13]([CH:14]([CH3:15])[CH3:16])[CH2:17][CH3:18])([CH3:19])[CH3:20].[Cl:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[OH:7])[cH:8][c:9]([Cl:11])[n:10]1.[Cl:77][CH2:78][Cl:79].[NH2:45][c:46]1[cH:47][cH:48][c:49]([Cl:71])[c:50](-[c:52]2[cH:53][c:54]3[c:55]([n:56][c:57]([NH:60][CH2:61][CH2:62][N:63]([CH3:64])[CH3:65])[n:58][cH:59]3)[n:66]([O:69][CH3:70])[c:67]2=[O:68])[cH:51]1.[O:82]=[CH:83][N:84]([CH3:85])[CH3:86].[P-:21]([F:22])([F:23])([F:24])([F:25])([F:26])[F:27].[n:28]1([O:29][C:30]([N:31]([CH3:32])[CH3:33])=[N+:34]([CH3:35])[CH3:36])[c:37]2[n:38][cH:39][cH:40][cH:41][c:42]2[n:43][n:44]1>>[Cl:1][c:2]1[cH:3][c:4]([C:5](=[O:7])[NH:45][c:46]2[cH:47][cH:48][c:49]([Cl:71])[c:50](-[c:52]3[cH:53][c:54]4[c:55]([n:56][c:57]([NH:60][CH2:61][CH2:62][N:63]([CH3:64])[CH3:65])[n:58][cH:59]4)[n:66]([O:69][CH3:70])[c:67]3=[O:68])[cH:51]2)[cH:8][c:9]([Cl:11])[n:10]1

Participants

10

Reactant 9

HCID 887MethanolHCID 6228DimethylformamideHCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 948302,6-Dichloroisonicotinic acidHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 584783586-(5-amino-2-chlorophenyl)-2-(2-(dimethylamino)ethylamino)-8-methoxypyrido[2,3-d]pyrimidin-7(8H)-one

Product 1

HCID 444643752,6-Dichloro-N-(4-chloro-3-(2-(2-(dimethylamino)ethylamino)-8-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-isonicotinamide

Sources & evidence

ORD record
ord-09d31d2bf91b4944a57cfc97490b0658
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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