Tetrahydrofuran → 1-Piperidinecarboxylic acid, 4-(aminocarbonyl)-4-phenyl-, 1,1-dimethylethyl ester

HRID 674529Notes

Reaction equation

HRID 674529 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([C:14](=[O:15])[OH:16])([c:17]2[cH:18][cH:19][cH:20][cH:21][cH:22]2)[CH2:12][CH2:13]1.[CH2:30]([O:31][C:32]([Cl:33])=[O:34])[CH:35]([CH3:36])[CH3:37].[CH2:38]1[O:39][CH2:40][CH2:41][CH2:42]1.[CH3:23][CH2:24][N:25]([CH2:26][CH3:27])[CH2:28][CH3:29]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([C:14](=[O:15])[NH2:25])([c:17]2[cH:18][cH:19][cH:20][cH:21][cH:22]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 62365Isobutyl chloroformateHCID 7369171-((Tert-butoxy)carbonyl)-4-phenylpiperidine-4-carboxylic acid

Product 1

HCID 227418011-Piperidinecarboxylic acid, 4-(aminocarbonyl)-4-phenyl-, 1,1-dimethylethyl ester

Sources & evidence

ORD record
ord-c879d073f70944918060ecd4cde55543
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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