Hydrochloric Acid → 4-(4-Amino-3-fluorophenoxy)-7-(1-methylpiperidin-3-ylmethoxy)quinoline-6-carbonitrile
Reaction equation
[C:16](=[O:17])([O-:18])[O-:19].[CH3:1][N:2]([CH3:3])[CH:4]=[O:5].[CH3:44][CH2:45][O:46][C:47](=[O:48])[CH3:49].[Cl:7][CH2:8][CH:9]1[CH2:10][N:11]([CH3:15])[CH2:12][CH2:13][CH2:14]1.[ClH:6].[K+:20].[K+:21].[NH2:22][c:23]1[c:24]([F:43])[cH:25][c:26]([O:27][c:28]2[cH:29][cH:30][n:31][c:32]3[cH:33][c:34]([OH:40])[c:35]([C:38]#[N:39])[cH:36][c:37]23)[cH:41][cH:42]1.[OH2:50]>>[CH2:8]([CH:9]1[CH2:10][N:11]([CH3:15])[CH2:12][CH2:13][CH2:14]1)[O:40][c:34]1[cH:33][c:32]2[n:31][cH:30][cH:29][c:28]([O:27][c:26]3[cH:25][c:24]([F:43])[c:23]([NH2:22])[cH:42][cH:41]3)[c:37]2[cH:36][c:35]1[C:38]#[N:39]Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-cc0489c5b28446f1a111b40d61ab7b53
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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