Ethylene Glycol → tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate

HRID 675346Notes

Reaction equation

HRID 675346 reaction equation
[C:9]([CH3:10])([CH3:11])([CH3:12])[O:13][C:14](=[O:15])[N:16]1[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]1.[CH3:34][CH:35]([OH:36])[CH3:37].[Cu:38]([I:39])[I:40].[I:1][c:2]1[cH:3][cH:4][c:5]([NH2:6])[cH:7][cH:8]1.[K+:27].[K+:28].[K+:29].[OH:30][CH2:31][CH2:32][OH:33].[P:22]([O-:23])([O-:24])([O-:25])=[O:26]>>[c:2]1([N:19]2[CH2:18][CH2:17][N:16]([C:14]([O:13][C:9]([CH3:10])([CH3:11])[CH3:12])=[O:15])[CH2:21][CH2:20]2)[cH:3][cH:4][c:5]([NH2:6])[cH:7][cH:8]1

Participants

8

Reactant 7

HCID 174Ethylene GlycolHCID 813Potassium Cation3×HCID 1061PhosphateHCID 3776IsopropanolHCID 108934-IodoanilineHCID 83717Copper iodideHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 11011301tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-db8cb10ad9e7441f909df2f6e551063e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

Loading…