Dimethylformamide → 4-Chloro-2-(2-hydroxy-1-hydroxymethyl-ethylamino)-8-(2,6-difluoro-phenyl)-8H-pyrido[2,3-d]pyrimidin-7-one
Reaction equation
[CH3:30][CH2:31][N:32]([CH2:33][CH3:34])[CH2:35][CH3:36].[Cl:1][c:2]1[c:3]2[c:4]([n:5][c:6]([S:8]([CH3:9])=[O:10])[n:7]1)[n:11](-[c:16]1[c:17]([F:23])[cH:18][cH:19][cH:20][c:21]1[F:22])[c:12](=[O:15])[cH:13][cH:14]2.[Cl:37][CH2:38][Cl:39].[NH2:24][CH:25]([CH2:26][OH:27])[CH2:28][OH:29].[O:40]=[CH:41][N:42]([CH3:43])[CH3:44]>>[Cl:1][c:2]1[c:3]2[c:4]([n:5][c:6]([NH:24][CH:25]([CH2:26][OH:27])[CH2:28][OH:29])[n:7]1)[n:11](-[c:16]1[c:17]([F:23])[cH:18][cH:19][cH:20][c:21]1[F:22])[c:12](=[O:15])[cH:13][cH:14]2Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-54c659d33542413aa5defcf56945dbfb
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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