反应详情

A mixture of 3-fluoroiodobenzene (8.88 g), 4-methyl-1-(2-propynyl)piperidine (6.80 g), palladium acetate (0.045 g), tri-o-toloylphosphine (0.24 g) and copper(I) iodide (0.1 g) in dry diethylamine (50 ml) was heated under reflux for 5 hours. The solvent was removed under reduced pressure and the residue was taken up in diethyl ether and washed with water. The organic phase was dried over magnesium sulfate and the solvent was removed under reduced pressure. Distillation of the residue under reduced pressure gave an oil (5.20 g) of boiling point 105° C./0.07 mm Hg.

1. temperaturewas heated
2. temperatureunder reflux for 5 hours
3. customThe solvent was removed under reduced pressure
4. washwashed with water
5. dry with materialThe organic phase was dried over magnesium sulfate
6. customthe solvent was removed under reduced pressure
7. distillationDistillation of the residue under reduced pressure