Hydrochloric Acid → [2-(2-Difluoromethoxy-phenyl)-5-(6-methyl-pyridin-3-yl)-[1,3,4]thiadiazol-3-yl]-(2-hydroxy-phenyl)-methanone
Reaction equation
[CH2:71]1[O:72][CH2:73][CH2:74][CH2:75]1.[CH3:76][OH:77].[ClH:70].[F:1][CH:2]([O:3][c:4]1[c:5]([CH:10]2[S:11][C:12]([c:27]3[cH:28][n:29][c:30]([CH3:33])[cH:31][cH:32]3)=[N:13][N:14]2[C:15](=[O:16])[c:17]2[c:18]([O:23][C:24](=[O:25])[CH3:26])[cH:19][cH:20][cH:21][cH:22]2)[cH:6][cH:7][cH:8][cH:9]1)[F:34].[F:35][CH:36]([F:37])[O:38][c:39]1[cH:40][cH:41][cH:42][cH:43][c:44]1[CH:45]1[N:46]([C:47]([c:48]2[c:49]([F:50])[cH:51][c:52]([F:53])[cH:54][c:55]2[F:56])=[O:57])[N:58]=[C:59]([c:60]2[cH:61][n:62][c:63]([CH3:64])[cH:65][cH:66]2)[S:67]1.[Li+:69].[OH-:68]>>[F:1][CH:2]([O:3][c:4]1[c:5]([CH:10]2[S:11][C:12]([c:27]3[cH:28][n:29][c:30]([CH3:33])[cH:31][cH:32]3)=[N:13][N:14]2[C:15](=[O:16])[c:17]2[c:18]([OH:23])[cH:19][cH:20][cH:21][cH:22]2)[cH:6][cH:7][cH:8][cH:9]1)[F:34]Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-40a4b544f06746a9ab771f0472d84846
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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