Triethylamine → Ethyl 4-[4-(1-methoxycyclopropyl)-phenylethynyl]-benzoate

HRID 679221Notes

Reaction equation

HRID 679221 reaction equation
[C:1](#[CH:2])[c:3]1[cH:4][cH:5][c:6]([C:9]2([O:12][CH3:13])[CH2:10][CH2:11]2)[cH:7][cH:8]1.[CH2:14]([CH3:15])[O:16][C:17]([c:18]1[cH:19][cH:20][c:21]([I:24])[cH:22][cH:23]1)=[O:25].[CH2:26]([N:27]([CH2:28][CH3:29])[CH2:30][CH3:31])[CH3:32].[Cu:33][I:34].[Pd:35]([Cl:36])[Cl:37].[c:38]1([P:39]([c:40]2[cH:41][cH:42][cH:43][cH:44][cH:45]2)[c:46]2[cH:47][cH:48][cH:49][cH:50][cH:51]2)[cH:52][cH:53][cH:54][cH:55][cH:56]1.[c:57]1([P:58]([c:59]2[cH:60][cH:61][cH:62][cH:63][cH:64]2)[c:65]2[cH:66][cH:67][cH:68][cH:69][cH:70]2)[cH:71][cH:72][cH:73][cH:74][cH:75]1>>[C:1](#[C:2][c:21]1[cH:20][cH:19][c:18]([C:17]([O:16][CH2:14][CH3:15])=[O:25])[cH:23][cH:22]1)[c:3]1[cH:4][cH:5][c:6]([C:9]2([O:12][CH3:13])[CH2:10][CH2:11]2)[cH:7][cH:8]1

Participants

7

Reactant 6

HCID 8471TriethylamineHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 142891Ethyl 4-iodobenzoateHCID 225689501-Ethynyl-4-(1-methoxycyclopropyl)-benzene

Product 1

HCID 22568838Ethyl 4-[4-(1-methoxycyclopropyl)-phenylethynyl]-benzoate

Sources & evidence

ORD record
ord-5dbea65444f548a5a3f9eeeaf9725b12
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

Loading…