Acetate → 3-[6-(2-Fluoro-phenyl)-pyridin-3-yl]-acrylic acid ethyl ester

HRID 679605Notes

Reaction equation

HRID 679605 reaction equation
[Br:30][c:31]1[cH:32][cH:33][c:34](-[c:37]2[c:38]([F:43])[cH:39][cH:40][cH:41][cH:42]2)[n:35][cH:36]1.[C:54]([O-:55])(=[O:56])[CH3:57].[C:59]([O-:60])(=[O:61])[CH3:62].[CH2:44]([CH3:45])[O:46][C:47]([CH:48]=[CH2:49])=[O:50].[CH3:23][CH2:24][N:25]([CH2:26][CH3:27])[CH2:28][CH3:29].[CH3:51][C:52]#[N:53].[Pd+2:58].[c:1]1([CH3:2])[cH:3][cH:4][cH:5][cH:6][c:7]1[P:8]([c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]1[CH3:15])[c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]1[CH3:22]>>[c:31]1([CH:49]=[CH:48][C:47]([O:46][CH2:44][CH3:45])=[O:50])[cH:32][cH:33][c:34](-[c:37]2[c:38]([F:43])[cH:39][cH:40][cH:41][cH:42]2)[n:35][cH:36]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 6342AcetonitrileHCID 8471TriethylamineHCID 8821Ethyl AcrylateHCID 80271Tri-o-tolylphosphineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 497585155-Bromo-2-(2-fluorophenyl)pyridine

Product 1

HCID 685379763-[6-(2-Fluoro-phenyl)-pyridin-3-yl]-acrylic acid ethyl ester

Sources & evidence

ORD record
ord-d0d2d3d1bd454fd0b3b879d52f3804dc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

Loading…