Tetrahydrofuran → 4-[5-(4-Methyl-piperazin-1-yl)-pyridin-3-yl]-2-(6-methyl-pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidine
Reaction equation
[Br:1][c:2]1[cH:3][c:4](-[c:8]2[c:9]3[c:10]([n:11][c:12](-[c:14]4[n:15][c:16]([CH3:20])[cH:17][cH:18][cH:19]4)[n:13]2)[nH:21][cH:22][cH:23]3)[cH:5][n:6][cH:7]1.[CH2:66]1[O:67][CH2:68][CH2:69][CH2:70]1.[CH3:24][N:25]1[CH2:26][CH2:27][NH:28][CH2:29][CH2:30]1.[CH3:57][Si:58]([N-:59][Si:60]([CH3:61])([CH3:62])[CH3:63])([CH3:64])[CH3:65].[CH:31]1([P:32]([CH:33]2[CH2:34][CH2:35][CH2:36][CH2:37][CH2:38]2)[c:39]2[cH:40][cH:41][cH:42][cH:43][c:44]2-[c:45]2[cH:46][cH:47][cH:48][cH:49][cH:50]2)[CH2:51][CH2:52][CH2:53][CH2:54][CH2:55]1.[Li+:56].[O:109]=[C:110]([CH:111]=[CH:112][c:113]1[cH:114][cH:115][cH:116][cH:117][cH:118]1)[CH:119]=[CH:120][c:121]1[cH:122][cH:123][cH:124][cH:125][cH:126]1.[O:73]=[C:74]([CH:75]=[CH:76][c:77]1[cH:78][cH:79][cH:80][cH:81][cH:82]1)[CH:83]=[CH:84][c:85]1[cH:86][cH:87][cH:88][cH:89][cH:90]1.[O:91]=[C:92]([CH:93]=[CH:94][c:95]1[cH:96][cH:97][cH:98][cH:99][cH:100]1)[CH:101]=[CH:102][c:103]1[cH:104][cH:105][cH:106][cH:107][cH:108]1.[Pd:71].[Pd:72]>>[c:2]1([N:28]2[CH2:27][CH2:26][N:25]([CH3:24])[CH2:30][CH2:29]2)[cH:3][c:4](-[c:8]2[c:9]3[c:10]([n:11][c:12](-[c:14]4[n:15][c:16]([CH3:20])[cH:17][cH:18][cH:19]4)[n:13]2)[nH:21][cH:22][cH:23]3)[cH:5][n:6][cH:7]1Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-145f014a59c245ebbbb24b3f498d7956
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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