Ammonium → [3-(4-Fluoro-3-methyl-phenyl)-2-hydroxy-propyl]-phosphonic acid diethyl ester

HRID 683190Notes

Reaction equation

HRID 683190 reaction equation
[Br-:1].[CH2:11]([CH3:12])[O:13][P:14]([O:15][CH2:16][CH3:17])(=[O:18])[CH2:19][CH:20]1[O:21][CH2:22]1.[CH2:25]1[O:26][CH2:27][CH2:28][CH2:29]1.[Cl-:23].[Cu:30][I:31].[F:2][c:3]1[c:4]([CH3:10])[cH:5][c:6]([Mg+:9])[cH:7][cH:8]1.[NH4+:24]>>[F:2][c:3]1[c:4]([CH3:10])[cH:5][c:6]([CH2:22][CH:20]([CH2:19][P:14]([O:13][CH2:11][CH3:12])([O:15][CH2:16][CH3:17])=[O:18])[OH:21])[cH:7][cH:8]1

Participants

8

Reactant 7

HCID 223AmmoniumHCID 259Bromide ionHCID 312ChlorideHCID 8028TetrahydrofuranHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 98446Diethyl 2,3-epoxypropylphosphonateHCID 178427977HCID 178427977, compound

Product 1

HCID 86585241[3-(4-Fluoro-3-methyl-phenyl)-2-hydroxy-propyl]-phosphonic acid diethyl ester

Sources & evidence

ORD record
ord-ba0973d8299d421288a30e5fdb71fa57
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

Loading…