反应详情

Intermediate c (9 g, 0.042 mol) was added to DMF (80 mL) under an ice bath. To the mixture was added NaH (1.3 g, 0.054 mol) in batch under an ice bath. After stirring for 30 min, benzyl bromide (3.1 mL, 0.042 mol) was added dropwise. After the dropwise addition, the reaction was conducted at 50° C. for 4 h. After completion of the reaction, the reaction solution was poured into water (300 mL). A great deal of solid separated out and was filtered by suction. The filtered cake was washed with water and dried to produce Intermediate j (8.1 g) in a yield of 81%.

1. additionAfter the dropwise addition
2. waitthe reaction was conducted at 50° C. for 4 h
3. customAfter completion of the reaction
4. customA great deal of solid separated out
5. filtrationwas filtered by suction
6. washThe filtered cake was washed with water
7. customdried