Tetrahydrofuran → (1-Benzhydrylazetidin-3-yl)methyl methanesulfonate

HRID 688108Notes

Reaction equation

HRID 688108 reaction equation
[Al+3:41].[CH2:58]1[O:59][CH2:60][CH2:61][CH2:62]1.[CH3:46][CH2:47][N:48]([CH2:49][CH3:50])[CH2:51][CH3:52].[CH3:53][S:54]([Cl:55])(=[O:56])=[O:57].[H-:40].[H-:43].[H-:44].[H-:45].[Li+:42].[c:1]1([CH:7]([N:8]2[CH2:9][CH:10]([CH2:12][OH:13])[CH2:11]2)[c:14]2[cH:15][cH:16][cH:17][cH:18][cH:19]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1.[c:20]1([CH:21]([c:22]2[cH:23][cH:24][cH:25][cH:26][cH:27]2)[N:28]2[CH2:29][CH:30]([C:31]([OH:32])=[O:33])[CH2:34]2)[cH:35][cH:36][cH:37][cH:38][cH:39]1>>[c:1]1([CH:7]([N:8]2[CH2:9][CH:10]([CH2:12][O:13][S:54]([CH3:53])(=[O:56])=[O:57])[CH2:11]2)[c:14]2[cH:15][cH:16][cH:17][cH:18][cH:19]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

9

Reactant 8

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 28486Lithium ionHCID 31297Methanesulfonyl chlorideHCID 104727Aluminum CationHCID 166653Hydride4×HCID 27354401-(Diphenylmethyl)azetidine-3-carboxylic acidHCID 2758715(1-Benzhydrylazetidin-3-yl)methanol

Product 1

HCID 21978370(1-Benzhydrylazetidin-3-yl)methyl methanesulfonate

Sources & evidence

ORD record
ord-68245d4d60c74a5dad848ff3c5c0320f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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