Hydrochloric Acid → N-[(2-chloro-3,4-difluorophenyl)methyl]-3-methyl-2-oxo-1-[6-(trifluoromethyl)-4-pyrimidinyl]-4-imidazolidinecarboxamide

HRID 690785Notes

Reaction equation

HRID 690785 reaction equation
[CH2:21]([N:22]1[CH2:23][CH2:24][O:25][CH2:26][CH2:27]1)[CH3:28].[CH2:41]([N:42]=[C:43]=[N:44][CH2:45][CH2:46][CH2:47][N:48]([CH3:49])[CH3:50])[CH3:51].[CH3:1][N:2]1[C:3](=[O:20])[N:4]([c:10]2[n:11][cH:12][n:13][c:14]([C:16]([F:17])([F:18])[F:19])[cH:15]2)[CH2:5][CH:6]1[C:7](=[O:8])[OH:9].[Cl:52][c:53]1[c:54]([CH2:61][NH2:62])[cH:55][cH:56][c:57]([F:60])[c:58]1[F:59].[Cl:63][CH2:64][Cl:65].[ClH:40].[OH2:29].[OH:30][n:31]1[c:32]2[cH:33][cH:34][cH:35][cH:36][c:37]2[n:38][n:39]1>>[CH3:1][N:2]1[C:3](=[O:20])[N:4]([c:10]2[n:11][cH:12][n:13][c:14]([C:16]([F:17])([F:18])[F:19])[cH:15]2)[CH2:5][CH:6]1[C:7](=[O:9])[NH:62][CH2:61][c:54]1[c:53]([Cl:52])[c:58]([F:59])[c:57]([F:60])[cH:56][cH:55]1

Participants

9

Reactant 8

HCID 313Hydrochloric AcidHCID 962WaterHCID 6344DichloromethaneHCID 7525EthylmorpholineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 671030001-(2-Chloro-3,4-difluorophenyl)methanamineHCID 671034023-Methyl-2-oxo-1-[6-(trifluoromethyl)-4-pyrimidinyl]-4-imidazolidinecarboxylic acid

Product 1

HCID 59252110N-[(2-chloro-3,4-difluorophenyl)methyl]-3-methyl-2-oxo-1-[6-(trifluoromethyl)-4-pyrimidinyl]-4-imidazolidinecarboxamide

Sources & evidence

ORD record
ord-fd3f9b2071934176bb362402fd401e0d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

Loading…