Picolinic acid → Diethyl 2-(5-bromopyridin-2-yl)malonate
Reaction equation
[Br:12][c:13]1[cH:14][cH:15][c:16]([I:19])[n:17][cH:18]1.[C:20](=[O:21])([O-:22])[O-:23].[CH2:1]([CH3:2])[O:3][C:4]([CH2:5][C:6](=[O:7])[O:8][CH2:9][CH3:10])=[O:11].[CH2:35]1[O:36][CH2:37][CH2:38][O:39][CH2:40]1.[Cs+:24].[Cs+:25].[Cu:41]([I:42])[I:43].[OH:26][C:27]([c:28]1[n:29][cH:30][cH:31][cH:32][cH:33]1)=[O:34]>>[CH2:1]([CH3:2])[O:3][C:4]([CH:5]([C:6](=[O:7])[O:8][CH2:9][CH3:10])[c:16]1[cH:15][cH:14][c:13]([Br:12])[cH:18][n:17]1)=[O:11]Participants
8
Sources & evidence
- ORD record
- ord-5fa21563e736452fb808b29023549b20
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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