1,2-Dichloroethane → Tert-butyl 4-(4-aminobenzoyl)piperazine-1-carboxylate

HRID 696132Notes

Reaction equation

HRID 696132 reaction equation
[CH2:11]([Cl:12])[CH2:13][Cl:14].[CH3:25][CH2:26][N:27]([CH2:28][CH3:29])[CH2:30][CH3:31].[N:32]1([C:38](=[O:39])[O:40][C:41]([CH3:42])([CH3:43])[CH3:44])[CH2:33][CH2:34][NH:35][CH2:36][CH2:37]1.[NH2:1][c:2]1[cH:3][cH:4][c:5]([C:8]([OH:9])=[O:10])[cH:6][cH:7]1.[Na+:46].[O:47]=[CH:48][N:49]([CH3:50])[CH3:51].[OH-:45].[OH:15][n:16]1[c:17]2[c:18]([cH:19][cH:20][cH:21][cH:22]2)[n:23][n:24]1>>[NH2:1][c:2]1[cH:3][cH:4][c:5]([C:8](=[O:10])[N:35]2[CH2:34][CH2:33][N:32]([C:38](=[O:39])[O:40][C:41]([CH3:42])([CH3:43])[CH3:44])[CH2:37][CH2:36]2)[cH:6][cH:7]1

Participants

9

Reactant 8

HCID 111,2-DichloroethaneHCID 923Sodium ionHCID 961HydroxideHCID 9784-Aminobenzoic AcidHCID 6228DimethylformamideHCID 8471TriethylamineHCID 757711-HydroxybenzotriazoleHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 2763355Tert-butyl 4-(4-aminobenzoyl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-93ea6f15aa57488c89157785ff1867cb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

Loading…