Hydrochloric Acid → 4-Amino-2-[(2-{[7-(2,4-dichlorophenyl)imidazo[1,2-c]pyrimidin-5-yl]amino}ethyl)amino]-1,3-thiazole-5-carbonitrile

HRID 696462Notes

Reaction equation

HRID 696462 reaction equation
[CH3:49][S:50]([CH3:51])=[O:52].[CH:38]([N:39]([CH2:40][CH3:41])[CH:42]([CH3:43])[CH3:44])([CH3:45])[CH3:46].[Cl:1][c:2]1[n:3][c:4](-[c:11]2[c:12]([Cl:18])[cH:13][c:14]([Cl:17])[cH:15][cH:16]2)[cH:5][c:6]2[n:7]1[cH:8][cH:9][n:10]2.[ClH:47].[F:19][C:20]([F:21])([F:22])[C:23]([OH:24])=[O:25].[NH2:26][c:27]1[n:28][c:29]([NH:34][CH2:35][CH2:36][NH2:37])[s:30][c:31]1[C:32]#[N:33].[OH2:48]>>[c:2]1([NH:37][CH2:36][CH2:35][NH:34][c:29]2[n:28][c:27]([NH2:26])[c:31]([C:32]#[N:33])[s:30]2)[n:3][c:4](-[c:11]2[c:12]([Cl:18])[cH:13][c:14]([Cl:17])[cH:15][cH:16]2)[cH:5][c:6]2[n:7]1[cH:8][cH:9][n:10]2

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 679Dimethyl SulfoxideHCID 962WaterHCID 6422Trifluoroacetic acidHCID 81531DiisopropylethylamineHCID 579117304-Amino-2-(2-aminoethylamino)-1,3-thiazole-5-carbonitrileHCID 59312932HCID 59312932, compound

Product 1

HCID 593130724-Amino-2-[(2-{[7-(2,4-dichlorophenyl)imidazo[1,2-c]pyrimidin-5-yl]amino}ethyl)amino]-1,3-thiazole-5-carbonitrile

Sources & evidence

ORD record
ord-2832b17aedd1495a903a77222c036a43
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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