Chloride → N-tert.-butyl-6-chloro-4-p-fluoro-phenyl-nicotinamide

HRID 696491Notes

Reaction equation

HRID 696491 reaction equation
[C:10]([CH3:11])([CH3:12])([CH3:13])[NH:14][C:15]([c:16]1[cH:17][n:18][c:19]([Cl:22])[cH:20][cH:21]1)=[O:23].[CH2:40]1[O:41][CH2:42][CH2:43][CH2:44]1.[CH3:24][OH:25].[Cl-:1].[Cl:26][C:27]1=[C:38]([Cl:39])[C:36](=[O:37])[C:33]([C:34]#[N:35])=[C:30]([C:31]#[N:32])[C:28]1=[O:29].[F:2][c:3]1[cH:4][cH:5][c:6]([Mg+:9])[cH:7][cH:8]1>>[F:2][c:3]1[cH:4][cH:5][c:6](-[c:21]2[c:16]([C:15]([NH:14][C:10]([CH3:11])([CH3:12])[CH3:13])=[O:23])[cH:17][n:18][c:19]([Cl:22])[cH:20]2)[cH:7][cH:8]1

Participants

7

Reactant 6

HCID 312ChlorideHCID 887MethanolHCID 67752,3-Dichloro-5,6-dicyano-1,4-benzoquinoneHCID 8028TetrahydrofuranHCID 11816697N-tert-butyl-6-chloronicotinamideHCID 178505839HCID 178505839, compound

Product 1

HCID 12167323N-tert.-butyl-6-chloro-4-p-fluoro-phenyl-nicotinamide

Sources & evidence

ORD record
ord-ee5aedb6612e40a9a332295d3636b668
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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