Triethylamine → 3-Methyl-1-(3-nitropyridin-4-yl)piperidin-3-ol

HRID 69924Notes

Reaction equation

HRID 69924 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[CH3:11][C:12]1([OH:18])[CH2:17][CH2:16][CH2:15][NH:14][CH2:13]1.C(N(CC)CC)C>CN(C=O)C>[CH3:11][C:12]1([OH:18])[CH2:17][CH2:16][CH2:15][N:14]([C:2]2[CH:7]=[CH:6][N:5]=[CH:4][C:3]=2[N+:8]([O-:10])=[O:9])[CH2:13]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 27357814-Chloro-3-nitropyridineHCID 224966263-Methylpiperidin-3-ol

Product 1

HCID 690415423-Methyl-1-(3-nitropyridin-4-yl)piperidin-3-ol

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Method 1 of Example 1 was followed using 1 equivalent each of 4-chloro-3-nitropyridine, 3-methylpiperidin-3-ol and triethyl amine in DMF yielding 3-methyl-1-(3-nitropyridin-4-yl)piperidin-3-ol. LCMS (m/z): 238.1 (MH+); LC Rt=1.39 min.

Sources & evidence

ORD record
ord-03f54a958d834c2cac0658e558fb6a14
Source dataset
uspto-grants-2014_09
Patent number
US08822497B2

Reaction notes

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