反应详情

To a solution of methyl 3-amino-6-cyclohexylpicolinate (1.0 equiv) in THF, at a concentration of 0.5 M, was added 1M LiOH (4.0 equiv). After stirring for 4 hours at room temperature, 1 N HCl (4.0 equiv.) was added and the THF was removed in vacuo. The resulting solid was filtered, rinsed with cold H2O (3×20 mL) yielding 3-amino-6-cyclohexylpicolinic acid (18%). LCMS (m/z): 221.0 (MH+); LC Rt=4.1 min

1. customthe THF was removed in vacuo
2. filtrationThe resulting solid was filtered
3. washrinsed with cold H2O (3×20 mL)