Tetrahydrofuran → N-(5-bromo-2,4-difluorophenyl)-2-methylpropanamide

HRID 701938Notes

Reaction equation

HRID 701938 reaction equation
[Br:1][c:2]1[c:3]([F:10])[cH:4][c:5]([F:9])[c:6]([NH2:7])[cH:8]1.[C:18]([CH:19]([CH3:20])[CH3:21])(=[O:22])[Cl:23].[CH2:24]1[O:25][CH2:26][CH2:27][CH2:28]1.[CH3:11][CH2:12][N:13]([CH2:14][CH3:15])[CH2:16][CH3:17]>>[Br:1][c:2]1[c:3]([F:10])[cH:4][c:5]([F:9])[c:6]([NH:7][C:18]([CH:19]([CH3:20])[CH3:21])=[O:22])[cH:8]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 62325Isobutyryl chlorideHCID 27832955-Bromo-2,4-difluoroaniline

Product 1

HCID 16757161N-(5-bromo-2,4-difluorophenyl)-2-methylpropanamide

Sources & evidence

ORD record
ord-932e41a37a014de3bbb896c4a488b887
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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