反应详情

温度

80 °C

A 60% dispersion of sodium hydride in mineral oil (40 g, 1 mol) was washed with dry petroleum ether and suspended in dry toluene (700 ml). The suspension was stirred under argon and carefully treated with a solution of 4-chlorophenol (128.6 g, 1 mol) in dry toluene (300 ml) added dropwise. The resulting suspension was stirred for 1 hour, warmed to 80° C. and treated with ethyl 2-chloroacetoacetate (165 g, 1 mol) added dropwise to maintain the internal temperature between 80°-85° C. The resulting solution was stirred at 80° C. for 4 hours, cooled and carefully treated with ice. The organic phase was washed with water (3×200 ml), 10% sodium hydroxide (2×75 ml), 75 ml), water (20 ml) and brine (100 ml), dried with magnesium sulfate, filtered and concentrated. The resulting oil was distilled in vacuo [bp 126°-132° C. (0.1 mm)]to give 95 g (37%) of ethyl 2-(4-chlorophenoxy)-acetoacetate.

1. additionadded dropwise
2. stirringThe resulting suspension was stirred for 1 hour
3. additionadded dropwise
4. temperatureto maintain the internal temperature between 80°-85° C
5. stirringThe resulting solution was stirred at 80° C. for 4 hours
6. temperaturecooled
7. additioncarefully treated with ice
8. washThe organic phase was washed with water (3×200 ml), 10% sodium hydroxide (2×75 ml), 75 ml), water (20 ml) and brine (100 ml)
9. dry with materialdried with magnesium sulfate
10. filtrationfiltered
11. concentrationconcentrated
12. distillationThe resulting oil was distilled in vacuo [bp 126°-132° C. (0.1 mm)]to